Symptomatic Fatigue was evaluated by the Krupp Fatigue Severity Score and motor performance of Adductor Pollicis by TransCranial Magnetic Stimulation, rapid voluntary movements and a fatiguing exercise test of a sustained 45-s isometric contraction.
The Motor Tests revealed baseline abnormal motor function and substantial Central Fatigue. After a 3-week course of 3,4-DiAminoPyridine (25-60 mg/day), six out of the eight patients reported substantial improvement in Fatigue and the group showed slightly less Fatigue on the exercise tests.
Other ElectroPhysiological tests of motor function were unchanged. The findings suggest that 3,4-DiAminoPyridine may play a role in the symptomatic treatment of Multiple Sclerosis Fatigue.However the mechanism behind such a benefit in Fatigue remains unclear and the discrepancy between subjective and more objective responses underlines the probable multifactorial nature of the PathoGenesis of this symptom in Multiple Sclerosis.
Brain, Volume 121, Issue 5: May 1998
GL Sheean1,*, NMF Murray1, JC Rothwell2, DH Miller1 and AJ Thompson1