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Multiple Sclerosis In Asians

  1. Anti-Aquaporin 4 AntiBody in Japanese Multiple Sclerosis: the presence of Optic Spinal Multiple Sclerosis without long Spinal Cord lesions and Anti-Aquaporin 4 AntiBody
    J Neurol NeuroSurg Psychiatry 2007 Sep;78(9):990-2

  2. Intrathecal activation of the IL-17/IL-8 axis in OpticoSpinal Multiple Sclerosis
    Brain 2005 May;128(Pt 5):988-1002

  3. Heat Shock Protein 70 gene polymorphism in Japanese with Multiple Sclerosis
    Tissue Antigens 2001 Aug;58(2):93-6

  4. Differences between T-Cell reactivities to major Myelin protein-derived peptides in OpticoSpinal and conventional forms of Multiple Sclerosis and healthy controls
    Tissue Antigens 2001 May;57(5):447-56

  5. Significant correlation between IL-10 levels and IgG indices in Multiple Sclerosis CerebroSpinal Fluid
    J NeuroImmunol 2000 Nov 1;111(1-2):64-67

  6. Optic-Spinal form of Multiple Sclerosis and Immune-mediated Myelopathy in Japan
    J Neural Transm Suppl 2000;(58):205-14

  7. Both the HLA-CPB1 and -DRB1 alleles correlate with risk for Multiple Sclerosis in Japanese: clinical phenotypes and gender as important factors
    Tissue Antigens 2000 Mar;55(3):199-205

  8. Genomic HLA profiles of MS in Hokkaido, Japan: important role of DPB1*0501 allele
    J Neurol 2000 Mar;247(3):175-8

  9. BrainStem and Cerebellar involvement in Japanese with Multiple Sclerosis - Genetic differences Must Read
    J Neurol NeuroSurg Psychiatry 1999 Aug;67(2):153-157

  1. NeuroImaging and functional analyzes for Multiple Sclerosis
    Rinsho Byori 2000 Sep;48(9):814-22

  2. HLA-DPB1*0501-associated OpticoSpinal Multiple Sclerosis: Clinical, neuroimaging and ImmunoGenetic studies
    Brain 1999 Sep;122(Pt 9):1689-1696





#1

NeuroImaging And Functional Analyzes
For Multiple Sclerosis

Kira J
Rinsho Byori 2000 Sep;48(9):814-22
Kyushu University, Graduate School of Medical Sciences, Dept of Neurology, Fukuoka, Japan
PMID# 11051795; UI# 20506014
Abstract

For NeuroImaging studies of Multiple Sclerosis (MS) lesions, Magnetic Resonance Imaging (MRI) is most useful, while Evoked Potentials (EPs) are commonly used for functional analyzes of Neural damage due to MS. This review summarizes the MRI and EP findings in MS.

MS lesions are visualized as high signal intensity lesions on T2-weighted images, Proton Density (PD)-weighted images, and Fluid-Attenuated Inversion Recovery(FLAIR) images, while such lesions demonstrate a low signal on T1-weighted images.

New MS lesions are usually enhanced by Gadolinium-DTPA on T1-weighted images, and the enhancement generally lasts 4 to 8 weeks.

In Asian patients with MS, OpticoSpinal MS (Asian-type MS) shows a significantly smaller numbers of Brain MRI lesions than conventional MS (Western-type MS.

While OpticoSpinal MS shows a significantly higher frequency of the Spinal Cord Atrophy on MRI than conventional MS. EPs are useful for detecting lesions located in certain portions of the Central Nervous System.

MRI is not sensitive enough to detect small lesions in the Optic Nerves and Spinal Cord, whereas EPs are sensitive for Optic Nerve and Spinal Cord lesions. Thus, combined use of MRI and EPs is required for the diagnosis and the optimal monitoring of disease activity in MS.



#2

OpticoSpinal Multiple Sclerosis: Clinical, NeuroImaging And ImmunoGenetic Studies

Yamasaki K, Horiuchi I, Minohara M, Kawano Y, Ohyagi Y, Yamada T, Mihara F, Ito H, Nishimura Y, Kira Ji
Brain 1999 Sep;122(Pt 9):1689-1696
Kyushu Univand Division of Immunogenetics, Graduate School of Medical Sciences, Neurological Institute and Dept of Radiology, Dept of Neurology, Kumamoto UnivGraduate School of Medical Sciences, Dept of NeuroScience and Immunology, Japan
PMID# 10468508
Abstract

In order to clarify the relationship between the clinical phenotype and the Human Leucocyte Antigen (HLA) in Multiple Sclerosis in Asians, 93 Japanese patients with Clinically Definite Multiple Sclerosis underwent clinical MRI and HLA-DPB1 Gene typing studies.

According to a Neurological Examination, 29 patients were classified as OpticoSpinal Multiple Sclerosis, 17 as Spinal Multiple Sclerosis and 47 as Western type Multiple Sclerosis.

Showing the involvement of multiple sites in the CNS including either the Cerebrum, Cerebellum or BrainStem.

The OpticoSpinal Multiple Sclerosis showed a significantly higher age of onset, higher Expanded Disability Status Scale scores and higher CSF cell counts and protein content than the Western type Multiple Sclerosis.

On Brain and Spinal Cord MRI, the OpticoSpinal Multiple Sclerosis showed a significantly lower number of Brain lesions.

But a higher frequency of Gadolinium-enhancement of the Optic Nerve and a higher frequency of Spinal Cord Atrophy than in Western type Multiple Sclerosis.

The frequency of the HLA-DPB1*0501 allele was found to be significantly greater in OpticoSpinal Multiple Sclerosis (93%) than in healthy controls (63%, corrected P value = 0.0091 and relative risk = 7.9).

But not in Western type Multiple Sclerosis (66%) or Spinal Multiple Sclerosis (82%).

The marked differences in the clinical and MRI findings, suggest that HLA-DPB1*0501-associated OpticoSpinal Multiple Sclerosis is a distinct subtype of Multiple Sclerosis.

As well as in the ImmunoGenetic backgrounds between the OpticoSpinal Multiple Sclerosis and Western-type Multiple Sclerosis together.



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