Make your own free website on Tripod.com

Cerebellar Deficit And Respiratory Impairment:
A Strong Association In Multiple Sclerosis?

Grasso MG, Lubich S, Guidi L, Rinnenburger D, Paolucci S
Acta Neurol Scand 2000 Feb;101(2):98-103
Rehabilitation Hospital, IRCCS S Lucia, Rome, Italy
PMID# 10685856; UI# 20148292
Abstract

The aim of the study was to analyze Pulmonary Function and to identify reliable prognostic factors associated with Respiratory abnormalities in a consecutive series of patients with Multiple Sclerosis (MS).

Pulmonary Function was evaluated by means of a battery of measures, including Maximal Voluntary Ventilation, Forced Vital Capacity, Forced Expiratory Volume, in 71 consecutive patients with Primary and Secondary/Progressive MS.

Respiratory impairment was common in MS patients, occurring in 63.4% of all patients, ranging from 82.9% in non-ambulatory patients (with EDSS score >6.5) to 35.7% in ambulatory patients (with EDSS score <6).

Severity of illness and Cerebellar and Mental Impairment were significantly negatively associated with Basal Pulmonary Function.

Coordination plays an important role in determining Respiratory abnormalities: Respiratory abnormalities were found in 27 out of 32 patients (84.4%) with severe Cerebellar impairment.

The presence of severe Cerebellar Signs was associated with a very high risk of occurrence of Respiratory impairment (O.R. = 6.24; 95% C.I. 1.71-22.82).

Other significant variables were severity of illness (EDSS score > 6.5) (O.R. =4.71; 95% C.I. 1.42-15.66) and long disease duration (> 15 years) (O.R. = 3.39; 95% C.I. 1.01-11.42).



Medical Texts
Anatomy | Immune System | Lymphocytes | Meds
MHC | Movement | Cranial Nerves | Physiology


MS Glossary ThJuland's MSers' Glen - Our CyberHome Page Top The Glen's Gallery: Come & Share Our Stories MS Files MS Abstracts Site Index


Abstracts
ANS | Bladder | Cognition | Fatigue | Fluid | Genetics
Interferons | IVIG | Nitric Oxide | Optic Neuritis | Pain
Physiology | Prions | Prognosis | ReMyelinate | Steroids
Stress | Treatments | TNF | Uric Acid | Viruses



Copyright 1997 - 2011:
Permission is granted to MS Societies and all MSers to utilize information from these pages provided that no financial reward is gained and attribution is given to the author/s.