Make your own free website on Tripod.com

Cognitive Function In P/P & T/P Multiple Sclerosis



Camp SJ, Stevenson VL, Thompson AJ, Miller DH, Borras C, Auriacombe S, Brochet B, Falautano M, Filippi M, Herisse-Dulo L, Montalban X, Parrcira E, Polman CH, De Sa J, Langdon DW
Brain 1999 Jul;122 ( Pt 7):1341-8
Institute of Neurology, Dept of Clinical Neurology, London, UK
PMID# 10388799; UI# 99318790
Abstract

The relative rarity of Primary/Progressive (PP) and Transitional/Progressive (TP) Multiple Sclerosis has meant that little documentation of Cognitive function in such patients is currently available.

The aim of this study was to investigate the Cognitive skills of patients with PP and TP Multiple Sclerosis relative to matched healthy controls, and to examine the relationship of this impairment to MRI parameters.

Sixty-three patients (43 PP, 20 TP) were individually matched with healthy controls, who undertook the same Cognitive tasks as the patient group. The NeuroPsychological assessment comprised Rao's brief repeatable battery, a reasoning test, and a measure of Depression.

Patients also underwent T1- and T2-weighted Brain MRI. These patients were taken from a larger cohort (158 PP, 33 TP) in whom it had been demonstrated that there were no significant differences between the mean scores of the PP and TP groups on any of the Cognitive variables.

The 63 patients were therefore taken as one group for comparison with the healthy controls. These patients performed significantly worse than the controls in tests of Verbal Memory, Attention, Verbal Fluency and Spatial Reasoning.

An impairment index was constructed and applied to the patient data. This correlated modestly with T2-Lesion Load (r = 0.45, P = 0.01), T1-HypoIntensity Load (r = 0.45, P = 0.01) and Cerebral Volume (r = -0.35, P = 0.01).

Thus, PP and TP Multiple Sclerosis patients demonstrate significant Cognitive Dysfunction when compared with matched healthy controls.

The relationship between this impairment and MRI parameters is moderate, suggesting that Cognitive Dysfunction in PP and TP Multiple Sclerosis has a complex and multifactorial Etiology, which is not adequately explained by pathology as demonstrated on conventional MRI.



Medical Texts
Anatomy | Immune System | Lymphocytes | Meds
MHC | Movement | Cranial Nerves | Physiology


MS Glossary ThJuland's MSers' Glen - Our CyberHome Page Top The Glen's Gallery: Come & Share Our Stories MS Files MS Abstracts Site Index


Abstracts
ANS | Bladder | Cognition | Fatigue | Fluid | Genetics
Interferons | IVIG | Nitric Oxide | Optic Neuritis | Pain
Physiology | Prions | Prognosis | ReMyelinate | Steroids
Stress | Treatments | TNF | Uric Acid | Viruses



Copyright 1997 - 2011:
Permission is granted to MS Societies and all MSers to utilize information from these pages provided that no financial reward is gained and attribution is given to the author/s.