Importance Of Determining Degree Of Atrophy As A Marker Of Disease Course
Spinal Cord Magnetic Resonance Imaging (MRI) is of particular interest in the management of Multiple Sclerosis (MS).
Especially in Primary/Progressive forms. Most of the DeMyelinating lesions are located in the Cervical or Dorsal Cord.
The aim of this study was to confirm this first result, to assess the reproducibility of this method and to correlate DeMyelinating Lesions with Spinal Cord Area reduction.
Fifty two patients were included and compared with 15 controls (normal subjects). T1 Sagittal and Axial plane images were performed to localized hypersignal lesions.
Spinal Cord area was obtained by a volume acquired inversion prepared Fast Spoiled Gradient Echo Acquisition (MP-Rage) sequence.
DeMyelinating lesions were found in 82p.100 of MS patients and in none of controls. Mean Spinal Cord area was closely similar to Losseff et al., 1996 results and was reduced compared with controls (p<0.001).
Spinal Cord reduction was correlated with disability, studied by the EDSS. Furthermore, no correlation was found between DeMyelinating lesions and Spinal Cord area reduction.