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Hormonal System

Hormonal System
CRF Effects On The Brain
Decreased

Eating

Sleeping

Reproductive activity

Increased

Restless activity in familiar environments

Withdrawal in unfamiliar environments

Hormonal System
Is known as the HypoThalamic-Pituitary-Adrenal Axis is active (solid arrows in diagram) in response to Stress Mounting evidence suggests that chronic overactivity of the Axis, and particularly overproduction of CorticoTropin-Releasing Factor (CRF), contributes to Depression.

For instance, application of CRF to the Brain of laboratory animals produces symptoms (above) similar to those often displayed by depressed individuals.


Image: Tomo Narashima