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Source:
Poser, CM; Paty, DW; Scheinber, L; et al.
Ann Neurol 1983; 13(3); 227-231
"New Diagnostic Criteria For Multiple Sclerosis; Guidelines For Research Protocols"



Diagnostic Categories for Multiple Sclerosis



Definite MS:

Consistent course (Relapsing/Remitting) with at least 2 bouts, separated by at least 1 month; or slow, stepwise Progressive course for at least 6 months
Documented Neurologic Signs of Lesions in more than one area (Functional System) of Brain or Spinal Cord White Matter
Onset of Symptoms between 10 and 50 years of age
Absence of other more likely Neurologic explanation


Probable MS: History of Relapsing/Remitting Symptoms
Signs not documented and only one current Sign, commonly associated with MS
Documented single bout of Symptoms with Signs, of more than one White Matter Lesion
Good recovery, then variable Symptoms and Signs
Absence of other more likely Neurologic explanation


Possible MS: History of Relapsing/Remitting Symptoms
No documentation of Signs establishing more than one White Matter Lesion
Absence of other more likely Neurologic explanation





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