Make your own free website on Tripod.com

Multiple Sclerosis Prevalence In The UK
Estimated By Capture-Recapture Methodology



Forbes RB, Swingler RJ
Am J Epidemiol 1999 Jun 1;149(11):1016-24
Ninewells Hospital and Medical School, Dept of Neurology,
Dundee, United Kingdom
PMID# 10355377; UI# 99281508
Abstract

The geographic distribution of Multiple Sclerosis is nonrandom, as the disease is more prevalent in Temperate than in Tropical regions. Surveys conducted between 1970 and 1996 suggest that Multiple Sclerosis is more prevalent in the Northern part of the United Kingdom than in the Southern part.

This North-South gradient ("the Latitudinal gradient") might be a methodological artifact, because high prevalence figures from serial surveys of the Northern part of the United Kingdom might have been the result of better ascertainment.

By using capture-recapture methods, the authors found that case ascertainment was similar in the Northern and Southern parts of the United Kingdom. When prevalence figures for Multiple Sclerosis in the Southern United Kingdom were increased to account for the number of unobserved cases, the difference persisted:

The prevalence of Multiple Sclerosis in the Northern part of the United Kingdom appeared to be at least 180 cases per 100,000 persons, whereas the maximum prevalence in the Southern part of the United Kingdom was less than 160 cases per 100,000 persons.

The distribution of Multiple Sclerosis in the United Kingdom is not uniform and is consistent with the hypothesis that populations with a high prevalence of Multiple Sclerosis may be Genetically predisposed to the disease.




Medical Texts
Anatomy | Immune System | Lymphocytes | Meds
MHC | Movement | Cranial Nerves | Physiology


MS Glossary ThJuland's MSers' Glen - Our CyberHome Page Top The Glen's Gallery: Come & Share Our Stories MS Files MS Abstracts Site Index


Abstracts
ANS | Bladder | Cognition | Fatigue | Fluid | Genetics
Interferons | IVIG | Nitric Oxide | Optic Neuritis | Pain
Physiology | Prions | Prognosis | ReMyelinate | Steroids
Stress | Treatments | TNF | Uric Acid | Viruses



Copyright 1997 - 2011:
Permission is granted to MS Societies and all MSers to utilize information from these pages provided that no financial reward is gained and attribution is given to the author/s.