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Glial Growth Factor 2 Lessens DeMyelination & Enhances Remyelination

Barbara Cannella*, Carolyn J. Hoban, Yan-Ling Gao*, Renee Garcia-Arenas, Deborah Lawson, Mark Marchionni, David Gwynne, and Raine CS*
The National Academy of Sciences: Vol. 95, Issue 17, 10100-10105, August 18, 1998
Albert Einstein College of Medicine, Neurology, and NeuroScience, Depts of * Pathology, 1300 Morris Park Avenue, Bronx, NY 10461; and Cambridge NeuroScience, Inc., One Kendall Square, Building 700, Cambridge, MA 02139
UI # 98374312
Abstract

Glial Growth Factor2 (GGF2) is a Neuronal signal that promotes the proliferation and survival of the Oligodendrocyte, the Myelinating cell of the Central Nervous System (CNS).

The present study examined whether recombinant human GGF2 (rhGGF2) could effect clinical recovery.

And, repair to damaged Myelin in chronic Relapsing Experimental AutoImmune EncephaloMyelitis (EAE) in the mouse, a major animal model for the human DeMyelinating disease, Multiple Sclerosis.

Mice with EAE were treated with rhGGF2 during both the acute and Relapsing phases.

Clinically, GGF2 treatment delayed signs, decreased severity, and resulted in statistically significant reductions in relapse rate.

rhGGF2-treated groups displayed CNS Lesions with more Remyelination than in controls.

This correlated with increased mRNA expression of Myelin Basic Protein exon 2, a marker for Remyelination, and with an increase in the CNS of the regulatory Cytokine, InterLeukin-10, at both the RNA and protein levels.

Thus, a beneficial effect of a Neurotrophic Growth Factor has been demonstrated on the clinical, pathologic, and molecular manifestations of AutoImmune DeMyelination, an effect that was associated with increased expression of a T-Helper2 Cytokine.

rhGGF2 treatment may represent a novel approach to the treatment of Multiple Sclerosis.



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