Mayne M, Krishnan J, Metz L, Nath A, Auty A, Sahai BM, Power C
Ann Neurol 1998 Sep;44(3):391-4
Univ of Manitoba, Dept of Medical Microbiology, Winnipeg, Canada
UI # 98420037
Several studies have suggested an association between Human HerpesVirus 6 (HHV-6) infection and Multiple Sclerosis.
As HHV-6 is predominantly a T-Cell Tropic Virus, we examined the frequency of detection of HHV-6 Genome in Peripheral Blood MonoNuclear Cells from:
- Relapsing/Remitting (n = 32)
- Chronic/Progressive (n = 14)
- Healthy (n = 17)
- Neurological Controls (n = 7)
Two sensitive Polymerase Chain Reaction Assays were used to target different regions within the HHV-6 Genome.
Depending on the Polymerase Chain Reaction Assay used, the detection of HHV-6 Genome ranged from:
- 11.7 to 23.5% - Controls
- 3.1 to 23.0% - Relapsing/Remitting
- 14.2 to 28.5% - Chronic/Progressive
Although these observations do not exclude a Pathogenic role for HHV-6 in Multiple Sclerosis, they indicate a lack of correlation between HHV-6 infection of Peripheral Blood MonoNuclear Cells and the development of MS.