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Human HerpesVirus-6 Infrequent In
Multiple Sclerosis MonoNuclear Cells


Mayne M, Krishnan J, Metz L, Nath A, Auty A, Sahai BM, Power C
Ann Neurol 1998 Sep;44(3):391-4
Univ of Manitoba, Dept of Medical Microbiology, Winnipeg, Canada
UI # 98420037
Abstract

Several studies have suggested an association between Human HerpesVirus 6 (HHV-6) infection and Multiple Sclerosis.

    As HHV-6 is predominantly a T-Cell Tropic Virus, we examined the frequency of detection of HHV-6 Genome in Peripheral Blood MonoNuclear Cells from:
    1. Relapsing/Remitting (n = 32)
    2. Chronic/Progressive (n = 14)
    3. Healthy (n = 17)
    4. Neurological Controls (n = 7)

Two sensitive Polymerase Chain Reaction Assays were used to target different regions within the HHV-6 Genome.

    Depending on the Polymerase Chain Reaction Assay used, the detection of HHV-6 Genome ranged from:
  • 11.7 to 23.5% - Controls
  •   3.1 to 23.0% - Relapsing/Remitting
  • 14.2 to 28.5% - Chronic/Progressive

Although these observations do not exclude a Pathogenic role for HHV-6 in Multiple Sclerosis, they indicate a lack of correlation between HHV-6 infection of Peripheral Blood MonoNuclear Cells and the development of MS.



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