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Interferon-gamma Secretion By Peripheral Blood T-Cell Subsets In Multiple Sclerosis

Becher B, Giacomini PS, Pelletier D, McCrea E, Prat A, Antel JP
Ann Neurol 1999 Feb;45(2):247-50
NeuroImmunology Unit, Montreal Neurological Institute, McGill University, Quebec, Canada
UI # 99142734
Abstract

Interferon-gamma (IFN-gamma) is implicated as a participant in the Immune Effector and Regulatory mechanisms considered to mediate the PathoGenesis of Multiple Sclerosis (MS).

We have used an IntraCellular Cytokine staining technique to demonstrate that the proportion of ex vivo peripheral blood CD4+ and CD8+ T-Cell subsets expressing IFN-gamma is increased in Secondary/Progressing (SP) MS patients.

Whereas the values in untreated Relapsing/Remitting (RR) MS patients are reduced compared with those of controls. Patients treated with Interferon-ß (IFN-ß) have an even more significant reduction in the percentage of IFN-gamma-secreting cells.

The finding that the number of IFN-gamma-expressing CD8+ Cells is increased in SPMS patients, a group with reduced functional Suppressor activity, and is most significantly reduced by IFN-ß therapy, which increases Suppressor activity, indicates that IFN-gamma secretion by CD8+ T-Cells and functional Suppressor defects attributed to this cell subset in MS can be dissociated.



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