A large cross-sectional Study
To substantiate differences in Magnetic Resonance (MR) patterns in clinical subgroups of Multiple Sclerosis (MS), we analyzed T2-weighted MR images of a large regional population of MS patients (n = 188).
The patients had already been classified according to recent consensus definitions regarding the clinical course of MS into Relapsing/Remitting (R/R), Secondary/Progressive (S/P) or Primary/Progressive (P/P).
Significant (p < 0.01; Spearman test) differences were present between R/R and S/P patients regarding total lesion load, size and location of lesions. R/R and P/P patients showed similar MR patterns.
The clinical progression rate [Expanded Disability Status Scale (EDSS)/disease duration] was similar for various subgroups; the MR progression rate (total lesion score/disease duration) was significantly larger for S/P than for P/P patients.
As the dynamics and clinical impact of MS lesions are different in the various clinical subgroups, they should be considered separately in clinical trials.