Book Medical
Ref# Condition Plain English Or Layman's Terminology
#9 ACTH Abbreviation for AdrenoCorticoTrophic Hormone;
used for short term treatment of an acute exa-
cerbation (attack), no value as a long term
treatment of MS.
#1 Acuity,Visual Clarity of vision. Visual acuity is expressed
as a fraction of normal vision. 20/400 means
an eye that sees at 20 feet what an average
eye sees at 400 feet.
(#17-3)
p83 Anoxia is a condition in which there is not enough
Oxygen for tissue Oxygenation.
#1 Anterior Horn In the Gray Matter of the Spinal Cord, it
(Spinal Cord) contains Motor Neurons. The Posterior Horn
(top) contains Sensory Neurons.
#2
Anterior Horn Cells They command Skeletal muscles to perform the
quick or the repetitive movements. They are the
final target of all Neural activity. Plaques or
DeMyelination anywhere in the CNS must affect
their function. ex: unstable Gait, or Incoordinate
fingers.
#1 Anterior Horn Cell A Motor Neuron in the Anterior Horn Gray
(Anterior Horn Neuron) Matter. These cells innervate muscle fibres
directly to produce movement of body parts.
#9 AntiBodies Substances produced by cells in response to
stimullating agents such as viruses or bacteria
they are tailor made for a particular Antigen.
#9 Antigen A molecular protein substance such as a virus,
Antigens stimulate an "Immune Response".
#1 Asymmetry Not the same on the two sides of the body.
#4 Ataxia The inability to maintain balance, while
p46 walking. The failure of muscular coordination.
#1 Atrophy,Optic Pallor and loss of blood vessels on the Optic
Nerve Head as is seen through the Ophthalmo-
scope. This is caused by loss of Myelin or of
Optic Nerve fibers and blood vessels in the
Optic Nerve.
#1 Babinski's When the sole of the foot is scratched, the big
Sign toe goes up instead of down. This is an indica-
tion (sign) that there is a lesion between the
p18 Motor Cortex on the opposite side of the Brain
and the lower Spinal Cord. This is a sign of
(plaque or lesion) Pyramidal Tract Disease.
#1 BrainStem That portion of the Brain that connects the
Cerebral Hemispheres with the Spinal Cord. It
has three major divisions: MidBrain, Pons, and
Medulla. This is the oldest part of the Brain,
where most involuntary functions are controlled
from.
#9 B-Cell A blood cell that makes proteins known as"Imm-
unoGlobulins."
#9 Cell The body is made up almost entirely of many
different kinds of cells. Each cell has a dis-
crete inner core called the Nucleus, surrounded
by CytoPlasm, and is encased in a membrane
separating it from other cells.
#9 Cellular One of the body's Immune systems.
Immunology
#1 Cell Membrane The thin layer made of Proteins, Fats and Car-
bohydrates, which form the Capsule of a cell,
and is its outside "skin".
#1 Cerebellum A part of the Brain located above the BrainStem
its chief function concerns Balance and Coordi-
nation of movements.
#2 Cerebellum Because Cerebellar activity never enters into
Consciousness, Cerebellar Disease is only dis-
p315 cernnible as complex Motor dysfunction. It has
no direct connection to any specific movement.
The Cerebellum has no ability to learn, hence
once damaged, it will always continue to mal-
function. ex: Posture Imbalance; Changes the
Speed and the Cadence of Speech; Willed Move-
Ments Resemble Tremor; and Abnormalities of Eye
Movements.
#20 Cerebellar Function Disorders
The severity of symptoms seems to depend on the
p112 amount of tissue destroyed and not on where the
damage is. Among the most characteristic signs
of Cerebellar damage are the following:
Asthenia
This refers to a lack of muscular strength,
either during voluntary muscle contraction or
in holding posture.
#20 Fatigability
p112 Muscles on the same side as where Cerebellar
damage has occurred tire more easily and have
slower than normal contraction and relaxtion
times, leading to slowed movements.
Hypotonia
The muscles feel flabby and offer less
resistance to passive displacement. This may be
from lack of response to Spinal Tract input.
Dysmetria
Literally "difficulty measuring" this term
refers to failure to stop a motion at the
intended point with overshoot occurring. Pre-
diction would seem to be faulty here.
Ataxia
This term indicates Incoordination of muscular
activity involving Tremor, Failure of Progres-
sion, and failure accurately to perform rapid
alternating movements such as tapping a finger.
A swaying, unsteady and wide based Gait is
often the most obvious Sign.
#9 Cerebrospinal The fluid surrounding the Brain and the Spinal
Fluid (CSF) Cord.
#1 Clonus Rapidly alternating contraction and relaxation
of a muscle. Aankle Clonus is the most common
form of Clonus. The spasms in the calf muscle
p18 makes the foot and leg bounce up and down. Is a
symptom of Spasticity.
#9 Complement A substance in Serum that combines with Antigen
AntiBody compound. Symbol C'
#1 Cortex Is the outer layer of any organ.
#1 Cortex, The outer layer of Nerve cells that covers the
Cerebral entire surface of the Cerebral Hemispheres.
Thinking and other complex Neuronal activity
occur in the Cerebral Cortex.
#1 Cortex The Cortex immediately adjacent to and closely
(Association) connected to the primary Sensory Cortex. Asso-
ciation Cortex gives form and meaning to raw
Sensory messages received at the Primary Senso-
ry Cortex thru widespread connections to many
parts of both sides of the Brain.
#1 DeMyelination Loss of the Myelin sheath that normally covers
a Nerve or an Axon.
#9 The destruction or removal of the Myelin cov-
ering Nerve tissue.
#1 Dendrite The part of a Neuron that carries impulses
towards the Cell Body.
#9 Disseminated Scattered or distributed (multiple).
Dyspepsia Indigestion, a feeling of being over stuffed.
Dysarthria Problems with the clarity or rhythm of speech.
(#17-3)
p82 Emboli are small particles that occlude (block) the
circulation of smaller blood vessels.
(#17-3)
p82 Embolization is the process of occlusion by Emboli.
#9 Encephalitis Inflalmmation of the Brain, sometimes called
"Sleeping Sickness" caused by viruses and
other microscopic organizms.
#9 Epidemiology The science concerned with the cause, frequency
and distribution of an infectious process or a
physiological state in a human community.
#1 Exacerbation An increase in the severity of symptoms.
Exacerbations of MS usually involve an increase
in definite symptoms, lasting weeks or months.
During the attack, numerous individual symptoms
may come and go in succession. Acute attacks
are usually followed by complete or partial
Remission - the abatement or diminution of
symptoms.
#1 Fasciculus, Medial A Nerve fiber tract in the BrainStem that helps
Longitudinal to control Horizontal Eye Movements. The (MLF)
coordinates the two eyes, when they look to the
left or to the right. A lesion in the MLF
interrups that coordination so that the eyes do
p18 not turn in precisely the same direction at
exactly the same time. Thereby producing two
images in the Brain of the same scene - Double
Vision.
#1 Gamma Globulin Blood proteins that carry AntiBody activity.
White Blood Cells in MS plaques make gamma glo-
bulins that may be found in the Spinal Fluid.
Increased percentage of Gamma Gloublin, and
p37 presence of OligoClonal Gamma Globulin bands
are characteristic of the Spinal Fluid in MS.
#9 - A protein fraction of the blood Serum which
contains many different kinds of AntiBodies.
#1 Gene The biological unit of heredity. Genes deter-
mine the structure and function of all proteins
in the body. In turn, these proteins govern
body shape and function.
#9 Genetic Pertaining to heredity, ie, HL-A Antigen.
Determinant
#1 Glands A collection of cells specialized to secrete
materials unrelated to their ordinary needs.
For instance, the Salivary Gland is a collec-
tion of cells that secrete saliva. Those cells
have no use for the product, which aids diges-
tion in the mouth and stomach.
(#17-3)
p82 Glial Scars are produced by enlargement of the
fibrils of Astrocytes (a type of Glia) that
normally support the Nerve cells and their
Nerve fibers. When a portion of the Nervous
System is damaged, these fibers enlarge and
replace the damaged area. This process is
referred to as Gliosis.
#20 Glial Cells Glial cells outnumber Neurons by about five to
one in the Nervous System. They have Processes
but do not form or conduct Nerve impulses.
p81 They possess the capacity to divide throughout
life. The following are included as types of
Glial cells and their assigned functions:
1 - Astrocytes are of two types, depending on
number and degree of branching of their
Processes. Fibrous Astrocytes have fewer and
less branched Processes; Protoplasmic (Mossy)
Astrocytes have more and highly branched
Processes. Both types of cells are believed to
be the major force creating cohesion of the
Central Nervous Tissue. In other words, they
hold things together and maintain the
structural relationship of the cells and their
vascular supply.
2 - Oligodendrocytes are Myelin forming cells
of the CNS. An internode of CNS Myelin is the
product of a single Oligodendrocyte.
3 - Ependymal Cells act as an Epithelial lining
for the Cavities within the CNS - Ventricles of
the Brain and Central Canal of the Spinal Cord.
Very small amounts of CerebroSpinal Fluid are
formed by secretion by these cells, and they
p83 form a part of the Choroid Plexuses of the
Brain, wherein the vast bulk of CerebroSpinal
fluid is formed by filtration and secretion
from the blood vessels composing the Plexuses.
4 - Microglia are sometimes called Brain
Macrophages. They seem to migrate into Nerve
tissue from the bloodstream, perhaps being
derived from blood cells called Monocytes.
They come to lie around both Neurons and
fobers, and remain quiesent until there is
injury or inflammation in the CNS. They then
become mobile, Phagocytic and assume a role
in cleaning up the traumatized area. They are
the only Mesodermally derived cells of the
Nervous System.
#20 5 - Satellite Cells are formed in Peripheral
p83 GanGlia and serve to support the Cell Bodies of
Neurons in those GanGlia.
6 - Schwann Cells are peripheral in location
and are involved in peripheral Myelin formation
and in the formation of the Neurilemma.
#1 Gray Matter Portions of the CNS where Nerve Cell Bodies are
concentrated. Cortex is Gray Matter. So are the
Anterior and Posterior Horns of the Spinal Cord
and more.
(#17-3)
p87 Hypoxia indicates a severe Oxygen shortage in tissue.
#9 Immunity Security against any particular disease or
poison, ie, Gamma Globulin.
#9 Interferon An interfering protein that neutralizes Virus.
It is produced by the body's cells in response
to foreign Nucleic Acid, such as Viruses. It
protects uninfected cells.
(#17-3)
p83 Ischemia is an insufficient blood supply to an organ
or tissue.
#1 Lateral A tract in the Anterior-Lateral portion of the
Spinothalamic Spinal Cord. Interruption of the LST results
Tract in Loss of Pain and Temperature Sensation below
p10-12 the level of the interruption on the opposite
side of the body.
#1 Lesion Any abnormal damage to tissue structure or fun-
ction. A scar is a lesion. So is Cancer, an MS
plaque, a Stomach Ulcer or a pimple.
#1 Lobe A major division of the Cerebral Hemisphere.
(Of the Brain) The Cerebral Hemisphere is divided into: Frontal
Lobe, Parietal Lobe, Occipital Lobe, Temporal
P13 Lobe, and Limbic Lobe.
#9 Lymphocyte A variety of white blood cells which are part
of the Immune systems of the body.
#1 Medulla The lowest major segment of the BrainStem.
(#17-3)
p82
Microemboli Refers to any small Emboli that predominantly
occlude the MicroCirculation.
#1 Myelin Fatty substance which forms a sheath around
some Nerve fibers in the CNS and the Peripheral
Nervous System. Myelin is formed by specialized
cells and consists largely of their cell membr-
anes, which wrap themselves around the Nerve
Axons.
#9 Myxovirus A Virus which causes disease in mucous tissue
such as the throat, mouth, or lung. (Influenza)
(#17-3)
p82 Necrosis is the death or decay of tissue in a part of
the body which is the result of loss of blood
supply, burning, and other severe injuries.
#1 Nerve Impulse The electrochemical charge carried by an Axon.
#1 Organelle Particles within cells that are covered with
(Little Organ) their own membrane. Many different kinds of
Organelle occur within cells, each with a
special function.
#1 Peripheral All the Nerves and Nerve cells outside the
Nervous System Central Nervous System.
#1 Plaque The DeMyelinating scarring of the Axons. Which
comprise the bulk of the White Matter in the
p26 Central Nervous System.
#1 Posterior Column Bundle of Axons in the Posterior part of the
Spinal Cord. Interruption of this column on one
side of the Spinal Cord causes loss of Position
p12 Sense below the level of the interruption on
the same side of the body.
#1 Protein Any of a large group of complex organic
compounds chiefly of Amino Acids. Proteins
govern the structure and function of all body
parts.
#1 Pyramidal Tract One of the major Motor tracts from the Brain to
(Corticospinal) the Spinal Cord. Its fibers form the Pyramids
#2 of the Medulla. It originates in the Cortex of
p313 the Frontal Lobe.
#2 It communicates directly with Motor Neurons in
the Anterior Horns of the Spinal Cord, to
activate fine Motor control ex: tying shoelaces
writing, etc.
#2 It orchestrates the Motor response and helps to
specify Body Posture at all levels of the
Spinal Cord.
#2 It adjusts Muscle Tone to counter the changing
centers of gravity.
#2 Plaque here causes the symptoms of Spasticity:
p314 Muscle Tightness, Ankle Clonus, Flexor Spasms,
Exhaustion, Loss Of Muscle Power and Paralysis.
#25 Romberg Sign Loss of Position Sense indicated by patient's
p453 inability to remain immobile with his feet
together and eyes closed.
#1 Segment One defined portion of the Spinal Cord, which
(Of The Spinal Cord) are: eight Cervical Segments (Neck & Upper ex-
tremities); twelve Thoracic Segments
(chest); five Lumbar Segments (lower trunk
& lower extremities); and five Sacral
Segments (buttocks, Bowel, Bladder and
Sexual function).
#9 Sequela A condition following or caused by a previous
disease; an aftereffect of illness.
#4 Spasticity Increased muscle tone - tightness or stiff
p84 muscles, usually around a joint.
#1 Symptom Any evidence of malfunction perceived by a
patient.
#1 Sign Any evidence of malfunction perceived by a
physican.
#20 Synapse The term Synapse refers to the anatomically
specialized junction between two Neurons. The
p83 end branches of a PreSynaptic Neuron's Axons
make contact with the Dendrites, Cell Body, or
Axon of a PostSynaptic Neuron. There is no
anatomical continuity between the two Neurons.
Synapses are of two types: chemical and
electrical. The chemical type predominates in
Mammalian Nervous Systems.
#9 Titer A level or strength of a substance such as
AntiBodies in Serum.
#1 Tract A bundle of Axons traveling together. In most
cases, the origin and destination of Axons in a
tract are quite similar.
#9 Virus A living agent, the smallest and simplest form
of life, which depends on other living cells in
order to reproduce itself. Discovered in 1898
#1 White Matter That part of the CNS containing mostly Axons,
their Myelin coating and supporting cells.
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