We studied 100 Multiple Sclerosis outpatients in order to assess the frequency of fatigue and to detect its relationships with other clinical findings.
Fatigue was quantified by Fatigue Severity Scale (FSS; range 1-7); current clinical Neurological status and Disability level were respectively scored by Kurtzke's Functional Systems and Expanded Disability Status Scale (EDSS).
Multiple regression analysis showed a significant effect of EDSS on Fatigue (p < 0.0001), not attributable to differences in disease duration.
FSS mean score was 4.12; Fatigue was totally absent in 3% of the patients. Fatigue started before onset of the disease in 7 patients, at onset in 12 and within the first year in 7 patients. Fatigue intensity and frequency were related to each other.