Make your own free website on Tripod.com

Cognitive Impairment In Multiple Sclerosis:
Changes In Normal-Appearing Brain Tissue

Filippi M, Tortorella C, Rovaris M, Bozzali M, Possa F, Sormani MP, Iannucci G, Comi G
J Neurol NeuroSurg Psychiatry 2000 Feb;68(2):157-161
Scientific Institute, Ospedale San Raffaele, NeuroImaging Research Unit, Dept of NeuroScience, Milan, Italy
PMID# 10644780
Abstract

Objectives
To assess whether:

  • The changes in the Normal-Appearing Brain Tissue (NABT), as revealed by Magnetization Transfer (MT) Histogram analysis, correlates with Cognitive Dysfunction in patients with Multiple Sclerosis

  • The relative contribution of these changes by comparison with that of Multiple Sclerosis lesions visible on conventional MRI

Methods
Dual echo, T1weighted and MT scans of the Brain were obtained in 12 patients with Multiple Sclerosis with Cognitive Impairment and in seven Without Cognitive Impairment. Lesion Loads were assessed from T2 and T1 weighted scans.

To create MTR Histograms of the NABT, Multiple Sclerosis Lesion outlines from Dual Echo scans were superimposed automatically and nulled out from the coregistered and scalp stripped MTR maps.

Average lesion MT Ratio (MTR) and Brain size were also measured.

Results
T2 and T1 lesion loads were significantly higher and the average lesion MTR and Brain size were significantly lower in the group of Cognitively Impaired patients.

Patients with Cognitive deficits also had significantly lower average MTR and peak location of the NABT Histogram.

Logistic regression analysis showed that 68% of the total variance was explained by average NABT-MTR alone.

A multivariable regression model showed that NABT-MTR was the only factor that significantly correlated with Cognitive Impairment in these patients (p=0.001).

Conclusions
The extent of abnormalities which go undetected when using conventional MRI is relevant in determining Cognitive Impairment in Multiple Sclerosis.



Medical Texts
Anatomy | Immune System | Lymphocytes | Meds
MHC | Movement | Cranial Nerves | Physiology


MS Glossary ThJuland's MSers' Glen - Our CyberHome Page Top The Glen's Gallery: Come & Share Our Stories MS Files MS Abstracts Site Index


Abstracts
ANS | Bladder | Cognition | Fatigue | Fluid | Genetics
Interferons | IVIG | Nitric Oxide | Optic Neuritis | Pain
Physiology | Prions | Prognosis | ReMyelinate | Steroids
Stress | Treatments | TNF | Uric Acid | Viruses



Copyright 1997 - 2011:
Permission is granted to MS Societies and all MSers to utilize information from these pages provided that no financial reward is gained and attribution is given to the author/s.