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Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection


Guidotti LG, Rochford R, Chung J, Shapiro M, Purcell R, Chisari FV
Science 1999 Apr 30;284(5415):825-829
The Scripps Research Institute, Dept of Molecular and Experimental Medicine,
La Jolla, CA 92037, USA

Univ of Michigan, Dept of Epidemiology,
Ann Arbor, MI 48109-2029, USA

Bioqual, Incorporated,
Rockville, MD 20850, USA.
The National Institutes of Health, Bethesda, MD 20892, USA


PMID# 10221919
Abstract
Viral clearance during hepatitis B virus (HBV) infection has been thought to reflect the destruction of infected Hepatocytes by CD8(+) T-Lymphocytes.

However, in this study, HBV DNA was shown to largely disappear from the Liver and the blood of acutely infected chimpanzees long before the peak of T-Cell infiltration and most of the Liver Disease.

These results demonstrate that NonCytopathic AntiViral mechanisms contribute to Viral clearance during Acute Viral Hepatitis by purging HBV replicative intermediates from the cytoplasm and covalently closed circular Viral DNA from the nucleus of infected cells.



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