Drulovic J, Drulovic J, Mesaros S, Samard ic T, Maksimovic D, Stojsavljevic N, Levic Z, Stojokvic MM
Mult Scler 2001 Feb;7(1):19-22
Clinical Centre of Serbia, Institute of Neurology, Belgrade, Yugoslavia
PMID# 11321188; UI# 21217486
A growing body of evidence implicates excessive generation of Nitric Oxide (NO) within the Central Nervous System (CNS) in Multiple Sclerosis (MS).
The aim of our study is to analyze Nitrite and Nitrate as end products of NO in the CerebroSpinal Fluid (CSF) from MS patients and correlate the concentrations with clinicol characteristics of the disease.
CSF nitrite and nitrate concentrations were measured after reduction of Nitrate, by Griess reaction, in 105 MS potients, 27 patients with Non-Inflammatory Neurological Disorders (NIND) and 13 individuals without Neurological Disorder (Co).
Mean CSF Nitrite and Nitrate concentrations were significantly higher in patients with MS and NIND compared with the Co patients (9.44 and 8.68, respectively, versus 6.85 microM; P=0.0001 and P=0.031, respectively).
There was no significant correlation between CSF Nitrite and Nitrate concentrations and activity, phase, severity and duration of MS.
Our data are in agreement with the results of previous studies which have demonstrated raised concentrations of CSF NO metabolites in MS patients, providing further evidence for NO involvement in MS.
The lack of correlation between NO metabolites and disease activity speaks in favor of the possible dual role of NO, as both ImmunoRegulatory and pro-inflammatory molecule, in the PathoGenesis of MS.
Krametter D, Niederwieser G, Berghold A, Birnbaum G, Strasser-Fuchs S, Hartung HP, Archelos JJ
Mult Scler 2001 Feb;7(1):13-8
Karl-Franzens-Universitat, Dept of Neurology, Graz, Austria
PMID# 11321187; UI# 21217485
Humoral Immune Responses to Chlamydia Pneumoniae (C. Pneumoniae) were studied in paired Sera and CerebroSpinal Fluid (CSF) of patients with definite Multiple Sclerosis (MS) and other Inflammatory and Non-Inflammatory Neurological Diseases.
Seropositivity was not significantly different between these groups. However, C. Pneumoniae-specific IgG titers were significantly higher in CSF of MS than in controls.
Sixteen out of 52 seropositive MS patients (30.8%) showed Intrathecal synthesis of C. Pneumoniae-specific IgG but only one of 43 seropositive controls (2.3%).
In MS, this was strongly associated with Intrathecal synthesis of PolyClonal IgG in 13/16 patients.
However, these elevated C. Pneumoniae antibody titers in CSF did not significantly correlate with disease duration, disease course, clinical or MRI disease activity, disability or presence of OligoClonal IgG in MS.
Postmarketing Survey Of Interferon-ß-1b
Oentrich W, Dose T, Friedmann D, Haupts M, Haller P, Hartung HP, Walther EU, Konig N, Schroder G, Sturzebecher CS
Nervenarzt 2001 Apr;72(4):286-92
Schering Deutschland GmbH, Max-Dohm-Strasse 10, 10589 Berlin
PMID# 11320864; UI# 21218320
In a survey of disease course, the efficacy and tolerability of 24-month Interferon-ß-1b therapy for Relapsing/Remitting Multiple Sclerosis (RRMS) were evaluated in 410 patients.
The investigation aimed at obtaining data from general practice and of possibly unknown, unexpected adverse reactions.
In the 241 patients still on therapy, efficacy was rated after 24 months as "good" or "very good" in 75% of cases. After 24 months, 36.9% of the patients had no exacerbation (baseline 0.3%).
Annual exacerbation rates dropped from 1.5 before treatment to 0.7 in the second treatment year. In the 2 years before treatment, 66.2% had worsened by at least 0.5 points on the Expanded Disability Status Scale (EDSS).
This proportion was reduced to 41.2% after 2 years of treatment. The safety profile corresponded to results from controlled trials.
This postmarketing survey supports data from the published controlled Interferon-ß-1b studies and confirms the main effects of this therapy under routine conditions in general practice.
The Influence Of Cognitive Impairment On Driving Performance In Multiple Sclerosis
Schultheis MT, Garay E, DeLuca J
Neurology 2001 Apr 24;56(8):1089-1094
Kessler Medical Rehabilitation Research and Education Corporation, NeuroPsychology and NeuroScience Laboratory, West Orange, NJ
To examine the influence of impaired Cognitive processing on measures of driving skills in persons with MS.
Twenty-eight subjects with documented MS were divided into two groups-with [MS(+), n = 13] and without [MS(-), n = 15] Cognitive Impairment-based on NeuroPsychological performance.
Healthy control (HC) subjects (n = 17) matched on age and driving experience were also studied.
Driving-related skills were compared between the groups based on performance on two computerized driving tests: the Useful Field of Vision (UFOV) and the NeuroCognitive Driving Test (NDT).
The MS(+) group performed significantly worse than both the MS(-) and HC groups in the latency to perform several driving-specific functions on the NDT, but no overall group differences were observed in actual errors on the NDT.
On the UFOV, when compared to MS(-) and HC subjects, the MS(+) group demonstrated poorer performance on two of the three subtests.
Additionally, a significantly higher percentage of MS(+) individuals were rated within the high risk (probability of crash involvement) category, relative to the MS(-) and HC groups.
Cognitive Impairment can negatively affect driving-related skills in persons with MS and should be considered in the determination of driving ability.
Learning Impairment Is Associated With Recall Ability In Multiple Sclerosis
Demaree HA, Gaudino EA, DeLuca J, Ricker JH
J Clin Exp Neuropsychol 2000 Dec;22(6):865-873
Kessler Medical Rehabilitation Research and Education Corporation, NeuroPsychology and NeuroScience Laboratory, West Orange, New Jersey and
UMDNJ-New Jersey Medical School, Depts of Physical Medicine and Rehabilitation, and NeuroSciences, Newark, United States of America
Recent evidence suggests that persons with Multiple Sclerosis may experience deficits in Verbal and VisuoSpatial acquisition rather than Recall.
The present study was designed to determine whether this finding generalized to a broader range of NeuroPsychological tests of Learning and Memory.
To control for group differences in information acquisition, healthy controls (HCs) and persons with Multiple Sclerosis (MS) were trained to specific learning criteria on both Verbal (i.e., paragraph learning and paired associates) and VisuoSpatial (i.e., facial recognition) Memory tasks.
Persons with MS required significantly more learning trials to meet criteria on the paragraph learning and facial recognition tasks, but not the paired associates test.
However, after learning comparable amounts of information, the MS and HC groups recalled statistically similar amounts of information at 30-minutes, 90-minutes, and up to 1-week on the paragraph learning and paired associate tests.
This suggests that persons with MS may have deficits in Acquisition rather than Recall per se. Results are discussed in terms of possible rehabilitation strategies to improve Memory functioning in persons with MS.