Levels of Tumor Necrosis Factor-alpha (TNF-), Granulocyte Macrophage-colony Stimulating Factor (GM-CSF), InterLeukin-10 (IL-10) and Transforming Growth Factor-beta (TGF-ß) in CerebroSpinal Fluid (CSF).
And Serum of 29 patients with Multiple Sclerosis (MS) of the Relapsing/Remitting type and of 20 controls with other NonInflammatory Neurological diseases were studied.
Sixteen patients were in the active phase of disease and 13 in remission. In CSF, higher IL-10 and TGF-ß concentrations were found in patients with a stable phase of MS, while in the active phase there were elevated levels of TNF- and GM-CSF.
These results suggest that a different Cytokine pattern could be involved in the PathoGenesis of Relapsing/Remitting MS.