1. It was Dr. Jean Martin Charcot (1825 - 1893) who first scientifically described, documented, and named the disease process, we still call Multiple Sclerosis.
2. The first patient Dr. Freud ever treated was his former Nanny, who had Multiple Sclerosis. *Creeping Paralysis* as it was called in those days, was considered a mental condition caused by *Female Hysteria*. As such, little or no extensive research was conducted into the mysteries of MS, until very recent times.
3. Dr. V.B. Dolgopol in 1938, described a case of Optic Neuritis, caused by severe DeMyelination and attributed it to Devic's Syndrone. This syndrone was considered to be a subclass of Multiple Sclerosis, during this time period.
4. Merck Manual - 16'th Edition - 1992
The Early History
|1400||- The earliest written record of someone with MS was Lydwina of Schieden, Dutch patron Saint of Ice Skaters.|
|1838||- Medical drawings clearly show what we today recognize as MS, but 19th century doctors did not understand what they saw and recorded.|
|1868||- Jean-Martin Charcot, professor of Neurology at the Univ of Paris, wrote the first complete description of MS and the changes in the Brain which accompany it.|
|1878||- Myelin was discovered by Dr. Ranvier.|
|1919||- Abnormalities in the Spinal Fluid were discovered in MS, but their signifigance remained puzzeling for decades.|
- Men were thought to be more susceptible to MS than
Because women were often mistakenly diagnosed with *hysteria* - MS symptoms tend to flair each month for most female MSers, about 2 weeks before each Menstrual Cycle for many.
ProstaGlandins, a group of Hormones found in Menstrual Fluid and many other tissues, may play a role.
|- Lord Edgar Douglas Adrian recorded the first electrical Nerve transmissions, which helped prove DeMyelinated Nerve cannot sustain electrical impulses.|
|1928||- The Oligodendrocyte cell that makes Myelin was discovered.|
|1935||- Dr. Thomas Rivers demonstrated that Nerve tissue, not Viruses, produced a MS-like illness. This animal form of MS, called EAE or Experimental Allergic EncephaloMyelitis, paved the way to our present theories of AutoImmunity, for it demonstrated the body can generate an Immunologic attack against itself.|
|1965||- White Blood Cells that react against a protein in Nerve insulating Myelin were discovered in MS.|
|1890's||- Caused by the supression of sweat; treated with herbs & bedrest; life expectancy after diagnosis was 5 years.|
|1910's||- Caused by an unknown blood toxin; treated with purgatives & stimulants; life expectancy after diagnosis was 10 years.|
|1940's||- Caused by blood clots & poor circulation; treated with drugs that improve circulation; life expectancy after diagnosis was 18 years.|
|1960's||- Caused by allergic reaction; treated with Vitamins & Antihistimines; life expectancy after diagnosis was 25 years.|
|1996||- Caused by AutoImmune reaction possibly linked to Virus; treated with Steriods & Immune System regulating drugs; life expectancy after diagnosis is essentially normal for most.|
NOTE: Life expectancy from time of diagnosis has increased over time as management and control of complications improved.
(Data based on research by: Loren A. Rolak, MD, Neurologist & Medical Historian, Marshfield MS Center, Marshfield, Wisconsin.)