CNS AutoImmunity Initiation & Regulation

Goverman J, Brabb T, Paez A, Harrington C, Von Dassow P
Crit Rev Immunol 1997; 17(5-6): 469-480
Univ of Washington, Dept of Molecular Biotechnology, Seattle 98195, USA
UI # 98080704

Our studies addressed the questions of how self-reactive T-Cells escape Tolerance and what stimuli cause these T-Cells to initiate AutoImmune Responses.

We employed Experimental Allergic EncephaloMyelitis (EAE) as an animal model of Multiple Sclerosis (MS).

Endogenous expression of Myelin Basic Protein (MBP) induces Tolerance in T-Cells that recognize one region of MBP, whereas T-Cells specific for a different region (Epitope) escape tolerance.

Triggers of disease induction were investigated in a T-Cell Receptor (TCR) TransGenic model in which the majority of T-Cells recognize the MBP Epitope that does not induce Tolerance.

EAE occurs spontaneously in this model and the incidence of disease depends on Microbial exposure.

EAE can also be actively induced by immunization with MBP Peptide accompanied by injection of Pertussis Toxin as well as by administration of Pertussis Toxin alone.

Immunization with MBP peptide without Pertussis Toxin, however, stimulates the TransGenic T-Cells, but the activated T-Cells do not accumulate in the Central Nervous System (CNS) or induce EAE.

Our studies suggest that initiation of AutoImmune Disease involves complex interactions between the NeuroEndocrine System as well as the Innate and Specific Immune Systems.

Medical Texts
Anatomy | Immune System | Lymphocytes | Meds
MHC | Movement | Cranial Nerves | Physiology

MS Glossary ThJuland's MSers' Glen - Our CyberHome Page Top The Glen's Gallery: Come & Share Our Stories MS Files MS Abstracts Site Index

ANS | Bladder | Cognition | Fatigue | Fluid | Genetics
Interferons | IVIG | Nitric Oxide | Optic Neuritis | Pain
Physiology | Prions | Prognosis | ReMyelinate | Steroids
Stress | Treatments | TNF | Uric Acid | Viruses

Copyright 1997 - 2011:
Permission is granted to MS Societies and all MSers to utilize information from these pages provided that no financial reward is gained and attribution is given to the author/s.