MS Prognosis

  1. Prognostic factors in Multiple Sclerosis
    Brain 1993 Feb; 116(Pt 1): 117-34

  2. Disability profile of MS did not change over 10 years in a population-based prevalence cohort
    Neurology 2004 Feb 24;62(4):601-6

  3. Bulk List
    Patterns of disease activity in Multiple Sclerosis

  4. Bulk List
    Natural history of MS Must Read

  5. Bulk List
    Multiple Sclerosis prognosis

  6. Bulk List
    Diagnosing Multiple Sclerosis

  7. Bulk List
    Cerebral Multiple Sclerosis lesions

  8. Bulk List: Spinal Cord in Multiple Sclerosis

  9. Bulk List: Benign Multiple Sclerosis
    Oldest, Newer, Newest

  10. Bulk List  Must Read
    Secondary/Pogressive Multiple Sclerosis

  11. Bulk List
    Transitional/Progressive Multiple Sclerosis

  12. Must Read Bulk List
    Primary/Progressive Multiple Sclerosis
       #1  ,  #2,   &  #3

  13. Bulk List
    MRI in Multiple Sclerosis Must Read

  14. Bulk List
    The PathoGenesis of Multiple Sclerosis

  15. Bulk List
    Multiple Sclerosis in children

  16. Bulk List
    Disability from Axonal damage

  17. Bulk List
    Impairment assessments in Multiple Sclerosis

  18. Bulk List
    Disability assessment in Multiple Sclerosis

  19. Bulk List
    Motor Evoked Potentials and Disability in Secondary/Progressive Multiple Sclerosis

  20. Bulk List
    Mortality statistics in Multiple Sclerosis

  21. High short-term MRI activity in S/P Multiple Sclerosis
    Brain 1998 Feb;121 ( Pt 2):225-31

  22. Differences in the dynamics of Progressive MS
    Ann Neurol 1991 Jan;29(1):53-62

  23. Long-term management of Multiple Sclerosis
    MS Management Vol 1 No 1, Apr 1994

  24. The lived experience of Relapsing Multiple Sclerosis: A phenomenological study
    J NeuroSci Nurs, 1997 Oct, 29:5, 294-304

  25. InterLeukin changes characterize different MS stages
    Ann Neurol 1999 Jun;45(6):695-703

  26. A Unifying Hypothesis on MS Etiology and Treatment
    Can J Neurol Sci, 1998 May, 25:2, 93-101

  27. CNS findings correlate with MS types and symptoms
    Brain, Volume 121, Issue 4: April 1998, pp. 687-697

  28. Systemic AutoImmune features & Multiple Sclerosis
    Arch Neurol May 1998;55:517-521

  29. Progress in determining MS causes and treatment
    Nature 1999 Jun 24;399(6738 Suppl):A40-7


MS Prognostic Factors

Runmarker B; Anderson, O
Brain 1993 Feb; 116(Pt 1): 117-34
Sahlgren's Hospital, Dept of Neurology, Goteborg, Sweden
PMID# 8453453; UI# 93201221

An incidence cohort consisting of 308 Multiple Sclerosis patients was followed up repeatedly during at least 25 years of disease.

A number of clinical factors were analyzed with respect to their validity in assessing the long-term prognosis.

Of the onset characteristics, the type of course was the most important, with Primary/Progressive patients experiencing a much more severe course.

In patients with an acute onset, low onset age, high degree of remission at first exacerbation, symptoms from Afferent Nerve fibers and onset symptoms from only one region:

As compared with polyregional symptoms of the Central Nervous System, were factors significantly associated with a favorable long-term prognosis.


Disability Profile Of MS Did Not Change Over 10 Years In A Population-Based Prevalence Cohort

Pittock SJ, Mayr WT, McClelland RL, Jorgensen NW, Weigand SD, Noseworthy JH, Rodriguez M
Neurology 2004 Feb 24;62(4):601-6
Mayo Clinic, Department of Neurology, Rochester, MN 55905, USA
PMID# 14981177

To assess whether the level of Multiple Sclerosis (MS) -related disability in the Olmsted County population has changed over a decade, and to evaluate how the rate of initial progression to moderate disability impacts further disability.

The Minimal Record of Disability (MRD) measured impairment, disability, and handicap for the 2000 (n = 201) prevalence cohort.

The authors compared these results with the 1991 (n = 162) cohort; 115 patients were in both cohorts.

The authors assessed retrospectively intervals at which Expanded Disability Status Scale (EDSS) scores of 3 (moderate disability), 6 (cane), and 8 (wheelchair) were reached.

The distribution of the 2000 EDSS and MRD scores were not significantly different from the 1991 distribution.

The median time from MS diagnosis, for the entire cohort, to EDSS scores of 3 and 6 was 17 and 24 years, respectively.

At 20 years after onset, only 25% of those with Relapsing/Remitting MS had EDSS scores > or =3. The median time from diagnosis to EDSS score of 6 for the Secondary and Primary/Progressive groups was 10 and 3 years, respectively.

Rate of progression from onset or diagnosis to EDSS score of 3 did not affect the rate of further disease progression.

However, once an EDSS score of 3 was reached, progression of disability was more likely, and rate of progression increased.

The distribution of Multiple Sclerosis disability in the Olmsted community has remained stable for 10 years.

Progression of disability for patients with Relapsing/Remitting Multiple Sclerosis or Secondary/Progressive Multiple Sclerosis may be more favorable than reported previously.

Once a clinical threshold of disability is reached, rate of progression increased.

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