MS Lassitude (Fatigue)

  1. Clinical aspects of fatigue in Multiple Sclerosis
    Funct Neurol 1997 Sep;12(5):247-251

  2. Fatigue in Multiple Sclerosis persists over time : A longitudinal study
    J Neurol 2006 Jun 13

  3. Association of Fatigue and Brain Atrophy in Multiple Sclerosis
    J Neurol Sci 2005 Feb 15;228(2):161-6

  4. Bulk Files - Fatigue in Multiple Sclerosis
    Newest# 3# 2# 1

  5. Bulk File - Frontal Cortex & Basal Ganglia in MS Fatigue & Cognitive Dysfunction

  6. Bulk Files
    4-AminoPyridine and Multiple Sclerosis

  7. The relationship of sleep disturbances and Fatigue in Multiple Sclerosis
    Arch Neurol 2004 Apr;61(4):525-8

  8. Fatigue in Multiple Sclerosis is associated with abnormal Cortical activation to voluntary movement-EEG evidence
    NeuroImage 2001 Jun;13(6):1186-92

  9. MRI and Motor Evoked Potential findings in nondisabled Multiple Sclerosis with and without symptoms of fatigue
    J Neurol 2000 Jul;247(7):506-9

  10. Contractile properties and fatigue of quadriceps in MS
    Muscle Nerve 2000 Oct;23(10):1534-1541

  11. Fatigue and exercise in Multiple Sclerosis
    Sports Med 1999 Mar;27(3):179-91

  12. The impact of fatigue in Multiple Sclerosis
    Can J Neurol Sci 1994 Feb;21(1):9-14

  13. Measurement of fatigue in Multiple Sclerosis
    Arch Neurol 1996;53:642-649

  14. Enermed (pulsed ElectroMagnetic Fields), alleviates MS Fatigue
    IFMSS: March 5, 1999

  15. 3,4-DiAminoPyridine in the treatment of MS fatigue
    Brain, Volume 121, Issue 5: May 1998

Clinical Aspects of Fatigue
In Multiple Sclerosis

Bergamaschi R, Romani A, Versino M, Poli R, Cosi V
Funct Neurol 1997 Sep;12(5):247-251
C. Mondino Institute of Neurology, Univ of Pavia, Italy
UI# 98103116

We studied 100 Multiple Sclerosis outpatients in order to assess the frequency of fatigue and to detect its relationships with other clinical findings.

Fatigue was quantified by Fatigue Severity Scale (FSS; range 1-7); current clinical Neurological status and Disability level were respectively scored by Kurtzke's Functional Systems and Expanded Disability Status Scale (EDSS).

FSS mean score was 4.12; Fatigue was totally absent in 3% of the patients. Fatigue started before onset of the disease in 7 patients, at onset in 12 and within the first year in 7 patients. Fatigue intensity and frequency were related to each other.

Multiple regression analysis showed a significant effect of EDSS on Fatigue (p < 0.0001), not attributable to differences in disease duration.

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