Epidemiology & Genetics
Of Multiple Sclerosis

  1. HLA-DP molecule involved in the development of MS
    Hum Immunol 59: 15-24 (1998)

  2. Risk alleles for Multiple Sclerosis identified by a genomewide study
    N Engl J Med 2007 Aug 30;357(9):851-62

  3. Heterogeneity at the HLA-DRB1 locus and risk for Multiple Sclerosis
    Hum Mol Genet 2006 Sep 15;15(18):2813-24

  4. HLA-DRB1*1501 risk association in Multiple Sclerosis may not be related to presentation of Myelin Epitopes
    J NeuroSci Res 2004 Oct 1;78(1):100

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    HLA-DR15 in Multiple Sclerosis

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    MHC Class II (HLA-DR2) and susceptibility to Multiple Sclerosis

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    Multiple Sclerosis in Africans

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    Multiple Sclerosis in Asians

  9. Must Read Bulk Listing
    Epidemiology of Multiple Sclerosis

  10. In vivo Gene expression revealed by cDNA arrays: the pattern in Relapsing/Remitting Multiple Sclerosis compared with controls
    J NeuroImmunol 2001 Jun 1;116(2):213-219

  11. Linkage analysis in Multiple Sclerosis of Chromosomal regions syntenic to Experimental AutoImmune Disease loci
    Eur J Hum Genet 2001 Jun;9(6):458-63

  12. Multiple Sclerosis in the Faroe Islands. An epitome
    J Clin Epidemiol 2001 Jan;54(1):1-22

  13. MHC Class II and the course and outcome of MS
    Neurology 51: 742-7 (1998)

  14. Association between gamma-Aminobutyric Acid A3 Receptor Gene (GABRA3) and Multiple Sclerosis
    Arch Neurol April,1998;55:513-516

  15. A genomic screen for Multiple Sclerosis underscores the MHC
    Nat Genet 13: 469-71 (1996)

  16. Multiple Sclerosis is linked to Caucasian ancestry
    Ann Neurol 36 Suppl: S22-4 (1994)

  17. The prevalence of Multiple Sclerosis in the United Kingdom
    Am J Epidemiol 1999 Jun 1;149(11):1016-24

  18. DRB1 Val86/Val86 genotype associates with Multiple Sclerosis in Australia
    Hum Immunol 1999 Aug;60(8):715-22

  19. Multiple Sclerosis in children under 6 years of age
    Neurology 1999 Aug 11;53(3):478-84

  20. Histocompatibility antigens in childhood Multiple Sclerosis
    Lik Sprava 1998 Aug;(6):67-9

  21. R/R & Monophasic nonR/R are ImmunoGenetically distinct in EAE
    J Immunol 1999 Mar 1;162(5):3096-3102

  22. Epidemiology: risk factors for Multiple Sclerosis in US veterans
    Neurology 1997 Jan 48:1 204-13

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HLA-DP Molecule Involved In
Multiple Sclerosis

Yu M; Kinkel RP; Weinstock-Guttman B; Cook DJ; Tuohy VK
Hum Immunol 59: 15-24 (1998)
Cleveland Clinic Foundation, Dept of Immunology, Cleveland, OH 44195, USA
UI# 98205876

Multiple Sclerosis (MS) is an AutoImmune DeMyelinating Disease of the Central Nervous System.

It is widely believed that complex polygenic inheritance patterns involving HLA-DR and -DQ Class II Genes contribute to MS susceptibility.

And, current evidence indicates that disease risk vs disease outcome may be associated with distinctly different HLA Class II alleles.

We have recently shown the early development of MS is accompanied by an extensive plasticity of Myelin Self-Recognition with the acquisition of NeoAutoReactivity, or Epitope spreading, as a prominent feature.

Although we did not observe a common determinant recognized by patients sharing identical HLA-DR or -DQ Class II alleles, we did observe Epitope spreading to the p50-63 determinant of Myelin ProteoLipid Protein (PLP) in two study subjects showing complete disparity at HLA-DR and -DQ but identity at the HLA-DP allele DPB1*0301.

In the present study we show that Self-Recognition during the early stages in the development of MS involves HLA-DP Class II restricted responses to the PLP 50-63 spreading determinant.

Our results suggest that self-presentation by HLA-DP may play an important role in Epitope spreading and in the propagation of Self-Recognition during the clinical progression of MS.

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