1. Callosal Atrophy in Relapsing/Remitting Multiple Sclerosis
    J Neurol 1998;245:153-8
  2. Longitudinal study of Callosal atrophy and InterHemispheric dysfunction in Relapsing/Remitting Multiple Sclerosis
    Arch Neurol 2001 Jan;58(1):105-111

  3. Study of performance of Delayed Intentions in Multiple Sclerosis
    J Clin Exp NeuroPsychol 2000 Jun;22(3):418-429
  4. Cortical/SubCortical disease burden and Cognitive Impairment in MS
    AJNR Am J NeuroRadiol 2000 Feb;21(2):402-8
  5. Changes in Normal-Appearing Brain Tissue and Cognitive Impairment in Multiple Sclerosis
    J Neurol NeuroSurg Psychiatry 2000 Feb;68(2):157-161
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  7. Bulk Abstracts - Cognitive Dysfunction In Multiple Sclerosis
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    Information processing speed: A key deficit in Multiple Sclerosis
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    Memory Capacity in Multiple Sclerosis
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  12. MRI study of Frontal Lobe Dementia in Multiple Sclerosis
    J Neurol Sci 1999 Dec 15;171(2):135-44
  13. Cognitive function in Primary/Progressive and Transitional/Progressive Multiple Sclerosis
    Brain 1999 Jul;122 ( Pt 7):1341-8
  14. NeoStriatum Cortical integration
    J Comp Neurol 1998 Mar 23;392(4):468-88
  15. Left Hemisphere dominance
    Brain, Volume 121, Issue 5: May 1998, pp. 785-799
  16. Lesion site patterns in Nonverbal Aphasia
    Arch Neurol 1998;55:1438-1448
  17. Pure Alexia & Word-Meaning Deafness in Multiple Sclerosis
    Arch Neurol 1998;55:1473-1474
  18. Psychomotor dysfunction & Callosal atrophy
    Acta Neurol Scand 1997 Dec;96(6):392-6
  19. Working memory impairment in early Multiple Sclerosis
    Brain 1997 Nov;120 ( Pt 11):2039-58
  20. Cognitive functioning evolves in Multiple Sclerosis
    Brain 1997 Feb 120 ( Pt 2): 289-97
  21. Executive functions in Multiple Sclerosis
    NeuroPsychology 1997 Oct;11(4):535-44
  22. Problem solving in Multiple Sclerosis
    J Int NeuroPsychol Soc 1996 Mar;2(2):134-140
  23. Cognitive Dysfunction screening in Multiple Sclerosis
    Arch Neurol 1996;53:980-984
  24. Cognitive disorders are common (45-65%) in Multiple Sclerosis
    Curr Opin Neurol 1995 Jun;8(3):216-20
  25. Relationship between Frontal Lobe Lesions and Wisconsin Card Sorting Test performance in Multiple Sclerosis
    Neurology 1994 Mar;44(3 Pt 1):420-5
  26. R/R vs R/P distribution of MS Brain lesions
    J NeuroImaging 1994 Oct;4(4):188-95

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Callosal Atrophy In
R/R Multiple Sclerosis

Barkhof FJ, Elton M, Lindeboom J, Tas MW, Schmidt WF, Hommes OR, Polman CH, Kok A, Valk J
J Neurol 1998;245:153-8
Free Univ Hospital, Dept of Diagnostic Radiology, Amsterdam, The Netherlands
PMID# 9553845, UI# 98214463

In Multiple Sclerosis (MS), PeriVentricular Lesions produce Atrophy of the Corpus Callosum (CC), as evidenced by Magnetic Resonance Imaging (MRI).

In this study, we sought to determine whether CC Atrophy is associated to Functional Deficits in patients with Relapsing/Remitting MS.

Using sagittal T1-weighted MRI, we compared CC size among 14 Relapsing/Remitting MS patients with mild disability (mean Expanded Disability Status Scale score, 2.7) and 14 controls matched for age and sex.

MRI measurements of the CC were correlated with functional measures, which consisted of a NeuroPsychological test battery and NeuroPhysiological evaluation based on Visual stimulation using a divided Visual Field Paradigm.

Total area of the CC was a mean 5.3 cm2 in MS patients, significantly smaller as compared to controls (mean, 6.6 cm2; P=.002). On the Dichotic Listening Test, MS patients demonstrated Left Ear Extinction

They performed more poorly than controls on the Name Learning Test; Impaired Name Learning was found to correlate with Atrophy of the Splenium. There was no significant differences between patients and controls in InterHemispheric Transfer Time.

Marked Atrophy of the CC was found in Relapsing/Remitting MS patients. There were no differences in InterHemispheric transfer time between patients and controls.

Marked Atrophy of the CC can be encountered in Relapsing/Remitting MS patients. The associated Cerebral Disconnection correlated with Atrophy of expected regions of the Corpus Callosum, thus supporting topographical organization.

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