Benign MS? Clinical Course, Long Term Follow Up, & Assessment Of Prognostic Factors

Hawkins SA, McDonnell GV
J Neurol NeuroSurg Psychiatry 1999 Aug;67(2):148-152
Northern Ireland Regional Neurology Service, Royal Victoria Hospital, Belfast, Northern Ireland, UK
PMID# 10406979

To establish the characteristics of patients following a Benign course of Multiple Sclerosis and evaluate the importance of potential prognostic factors.

Also, an assessment of the value of the Kurtzke EDSS as a prognostic indicator has been undertaken in patients previously determined to have Benign Multiple Sclerosis, after 10 years of follow up.

A prevalence study in the Coleraine, Ballymena, Ballymoney, and Moyle districts of Northern Ireland used the Kurtzke Expanded Disability Status Scale (EDSS) in 259 patients with Multiple Sclerosis.

Of these, 181 had had Multiple Sclerosis for >/=10 years, 36 having Benign disease (EDSS </=3.0) >/=10 years after Onset. Clinical and demographic details of the various patient groups, including the Minimal Record Of Disability (MRD), were compared.

The 1987 study in Northern Ireland identified 33 patients with Benign Multiple Sclerosis. Twenty eight were available for follow up in 1996 along with 42 contemporary Non-Benign patients.

Patients with Benign Multiple Sclerosis were predominantly women (ratio 4.1:1 v 2.1:1) and younger at Onset (25.8 v 31.2 years).

Commonest symptoms at Onset were Sensory and Optic Neuritis (33.3% each). Optic Neuritis was significantly more common in those with a younger age at Onset.

Patients with late Onset (older than 40 years) were less likely to have a Benign course, more likely to have a Progressive course from Onset, significantly more likely to have Motor Disturbance at presentation, and had a lesser female predominance.

In the follow up study, patients with Benign Multiple Sclerosis continued to have a more favorable course than Non-Benign counterparts but progression of disability and to the Secondary/Progressive phase remained significant.

The association of female sex, early Onset, and presentation with Optic Neuritis and Sensory symptoms with a favorable course is confirmed.

However, although the EDSS does provide a useful indicator of prognosis, the label "Benign Multiple Sclerosis" is often temporary as apparently Benign disease often becomes disabling.

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