The ImmunoPathology Concepts Of Multiple Sclerosis Lesions

Lassmann H, Vass K
Springer Semin Immunopathol 1995;17(1):77-87
Univ of Vienna,
Neurological Institute,
Wien, Austria
PMID# 7482228; UI# 96100786

ImmunoPathological studies on Multiple Sclerosis (MS) Brain clearly indicate that a T-Cell mediated Immune Response is the driving force in the induction of the lesions.

This T-Cell mediated response alone, however, is not sufficient to explain the widespread and selective destruction of Myelin sheaths.

According to present evidence, it is likely that AntiBodies directed against surface components of Myelin sheaths are at least one factor involved in the DeMyelinating process.

The patterns of inflammation, DeMyelination and Oligodendrocyte destruction, however, suggest that the PathoGenesis of the lesions may be fundamentally different in individual MS patients and that AutoImmunity may not be the sole cause.

In the case of AutoImmune reactions various different proteins of the Nervous System may become targets and it appears unlikely, that Myelin Basic Protein is a major candidate for a PathoGenetic role in MS.

Medical Texts
Anatomy | Immune System | Lymphocytes | Meds
MHC | Movement | Cranial Nerves | Physiology

MS Glossary ThJuland's MSers' Glen - Our CyberHome Page Top The Glen's Gallery: Come & Share Our Stories MS Files MS Abstracts Site Index

ANS | Bladder | Cognition | Fatigue | Fluid | Genetics
Interferons | IVIG | Nitric Oxide | Optic Neuritis | Pain
Physiology | Prions | Prognosis | ReMyelinate | Steroids
Stress | Treatments | TNF | Uric Acid | Viruses

Copyright 1997 - 2010:
Permission is granted to MS Societies and all MSers to utilize information from these pages provided that no financial reward is gained and attribution is given to the author/s.