NeuroTransmitters Change In Multiple Sclerosis

  1. Catecholamine levels in Multiple Sclerosis Peripheral blood Lymphocytes
    J NeuroImmunol 2002 Mar;124(1-2):93-100

  2. NeuroTransmitters change in Multiple Sclerosis
    NeuroSci Behav Physiol 1998 Jul-Aug;28(4):341-4


Catecholamine Levels In Multiple Sclerosis Peripheral Blood Lymphocytes

Rajda C, Bencsik K, Vecsei L L, Bergquist J
J NeuroImmunol 2002 Mar;124(1-2):93-100
University of Szeged, Department of Neurology, Semmelweis u. 6, H-6725 Szeged, Hungary
PMID# 11958826

Circumstantial evidence suggests the involvement of SympathoAdrenergic mechanisms in the progress of Multiple Sclerosis (MS). We studied Peripheral Blood Lymphocytes from MS patients.

The levels of Dopamine (DA), NorEpinephrine (NE), Epinephrine (E) and their metabolites in extracts of Lymphocytes from 58 MS patients and 19 healthy controls were measured by using Capillary ElectroPhoresis.

The MS patients were divided into clinical subgroups: a Laboratory-Supported Definitive (first-attack) MS group, and a Relapsing/Remitting (RR) group in remission.

The Peripheral blood Lymphocyte level of Epinephrine was significantly higher in the first-attack MS patients (p=0.028) than in the controls.

However, the NorEpinephrine levels were significantly (p=0.027) lower in the RR patients in remission. The Catecholamines are known to be able to affect the Lymphocyte activity, both by stimulation and by ImmunoSuppression.

Our results suggest that the CatecholAmines are important regulators of Lymphocyte activation in MS, and of potential importance as concerns new diagnostic and therapeutic methods.


NeuroTransmitters Change In Multiple Sclerosis

Barkhatova VP, Zavalishin IA, Askarova LS, Shavratskii VK, Demina EG
NeuroSci Behav Physiol 1998 Jul-Aug;28(4):341-4
Russian Academy of Medical Sciences, Institute of Neurology, Moscow
PMID# 9762701; UI# 98435449

Patients with Multiple Sclerosis were found to have increased CerebroSpinal Fluid, NorAdrenalin, and Excitatory Amino Acid (Glutamate and Aspartate) levels, with increased Blood Glutamine, Asparagine, and Glycine levels.

An association was found between these biochemical parameters and the nature and severity of Neurological symptoms, as well as with the course of the disease.

NeuroTransmitters are proposed to have a role in the PathoGenesis of Multiple Sclerosis, particularly in the biochemical mechanisms of the relationship between the Nervous and Immune Systems, as well as in the NeuroChemical mechanisms underlying the development of Neurological Deficit.

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