Urinary Tract Infections May Trigger Relapse In Multiple Sclerosis

Metz LM, McGuinness SD, Harris C
Axone 1998 Jun;19(4):67-70
Multiple Sclerosis Clinic,
Foothills Hospital,
Calgary, AB
PMID# 9849133; UI# 99065995

Multiple Sclerosis (MS), a DeMyelinating disease of the Central Nervous System, is the most common neurological disease affecting young adults in North America and, in the majority of cases, is associated with accumulating disability.

Urinary Tract Dysfunction affects up to 90% of the MS population, and Urinary Tract Infections are encountered in up to 74% of the tested population.

Viral infections have previously been shown to trigger acute exacerbation and it is our experience that Urinary Tract Infection also commonly precedes relapse, and, when recurrent, is associated with Neurologic Progression.

We present three case studies from our MS Clinic where recurrent UTI was associated with acute exacerbation and Neurologic Progression refractory to IntraVenous Steroid treatment.

Interferons, protein signaling molecules, have recently been found to play a role in acute exacerbation and disease progression in individuals with MS.

Viral infections induce Interferon release which may activate T-Cells to produce Interferon-gamma (Interferon-gamma).

Interferon-gamma precipitates relapse and stimulates production of Tumor Necrosis Factor-alpha (TNF-alpha), a Cytokine directly toxic to Oligodendrocytes.

Bacterial infections similarly induce Interferon release and may activate Immune pathways that result in MS Exacerbation and Neurologic Progression.

Medical Texts
Anatomy | Immune System | Lymphocytes | Meds
MHC | Movement | Cranial Nerves | Physiology

MS Glossary ThJuland's MSers' Glen - Our CyberHome Page Top The Glen's Gallery: Come & Share Our Stories MS Files MS Abstracts Site Index

ANS | Bladder | Cognition | Fatigue | Fluid | Genetics
Interferons | IVIG | Nitric Oxide | Optic Neuritis | Pain
Physiology | Prions | Prognosis | ReMyelinate | Steroids
Stress | Treatments | TNF | Uric Acid | Viruses

Copyright 1997 - 2010:
Permission is granted to MS Societies and all MSers to utilize information from these pages provided that no financial reward is gained and attribution is given to the author/s.