CerebroSpinal Fluid & Serum Cytokines In Relapsing/Remitting Multiple Sclerosis

Carrieri PB, Provitera V, De Rosa T, Tartaglia G, Gorga F, Perrella O
Immunopharmacol Immunotoxicol 1998 Aug;20(3):373-82
Univ of Naples Federico II, Dept of Neurological Sciences, Naples, Italy
UI # 98405849

Levels of Tumor Necrosis Factor-alpha (TNF-alpha), Granulocyte Macrophage-colony Stimulating Factor (GM-CSF), InterLeukin-10 (IL-10) and Transforming Growth Factor-beta (TGF-ß) in CerebroSpinal Fluid (CSF).

And Serum of 29 patients with Multiple Sclerosis (MS) of the Relapsing/Remitting type and of 20 controls with other NonInflammatory Neurological diseases were studied.

Sixteen patients were in the active phase of disease and 13 in remission. In CSF, higher IL-10 and TGF-ß concentrations were found in patients with a stable phase of MS, while in the active phase there were elevated levels of TNF-alpha and GM-CSF.

These results suggest that a different Cytokine pattern could be involved in the PathoGenesis of Relapsing/Remitting MS.

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