Clinical, NeuroPhysiological, And MRI Correlations
In Multiple Sclerosis


Comi G, Filippi M, Rovaris M, Leocani L, Medaglini S, Locatelli T
J Neurol NeuroSurg Psychiatry 1998 May;64 Suppl 1:S21-5
Univ of Milan, Dept of Clinical NeuroPhysiology, Scientific Institute H San Raffaele, Milan, Italy
PMID# 9647280; UI# 98309495
Abstract

Magnetic Resonance Imaging (MRI) has a pivotal role in the diagnosis of Multiple Sclerosis and is being increasingly used as a paraclinical measure to assess treatment efficacy in clinical trials.

However, the correlations between clinical and MRI findings in patients with Multiple Sclerosis are weak and, therefore, newer MR techniques are being developed to increase both MRI sensitivity for detecting disease activity and its pathological specificity for better assessing disease evolution.

Evoked Potentials (EPs) can be used to confirm the diagnosis of Multiple Sclerosis and their abnormalities are correlated with symptoms and Signs referable to involvement of the corresponding Nervous Pathways.

However, their use is limited when assessing disease progression and monitoring clinical trials in Multiple Sclerosis.

Both Magnetic Resonance Imaging (MRI) and Evoked Potentials (EPs) provide information which cannot be obtained by clinical evaluation, especially for assessing disease activity.

Nevertheless, both these paraclinical techniques cannot substitute for clinical measures of Disability when assessing disease progression and monitoring Phase III Clinical Trials in Multiple Sclerosis.



Medical Texts
Anatomy | Immune System | Lymphocytes | Meds
MHC | Movement | Cranial Nerves | Physiology


MS Glossary ThJuland's MSers' Glen - Our CyberHome Page Top The Glen's Gallery: Come & Share Our Stories MS Files MS Abstracts Site Index


Abstracts
ANS | Bladder | Cognition | Fatigue | Fluid | Genetics
Interferons | IVIG | Nitric Oxide | Optic Neuritis | Pain
Physiology | Prions | Prognosis | ReMyelinate | Steroids
Stress | Treatments | TNF | Uric Acid | Viruses



© Copyright 1997 - 2011:
Permission is granted to MS Societies and all MSers to utilize information from these pages provided that no financial reward is gained and attribution is given to the author/s.