Spinal MRI In Suspected Multiple Sclerosis & Negative Brain MRI

Thorpe JW, Kidd D, Moseley IF, Thompson AJ, MacManus DG, Compston DA, McDonald WI, Miller DH
Brain 1996 Jun;119 ( Pt 3):709-14
Institute of Neurology, NMR Research Unit, London, UK
PMID# 8673484; UI# 96285357

Although MRI detects the White Matter lesions of Multiple Sclerosis within the Brain with high sensitivity, a minority of patients have normal Brain MRI.

We describe 20 patients, selected from over 170 who had undergone Brain imaging with minimal (n = 12) or no (n = 8) abnormalities (median number of Lesions = I, range, 0-3) but in whom Spinal MRI was abnormal.

Twelve had Clinically Definite or Laboratory Supported Definite Multiple Sclerosis according to the Poser's Criteria; one had clinically Probable disease and seven, not fulfilling the Poser Criteria, were classified as Possible Multiple Sclerosis.

All had presented with symptoms and signs referable to the Spinal Cord or Optic Nerves. Eleven had a Primary/Progressive course, eight Relapsing/Remitting and only one Secondary/Progressive MS.

Moderate or severe Disability was the rule in the Primary/Progressive cases; all the Relapsing/Remitting patients had minimal disability. All had at least one lesion visible in the Spinal Cord (median 2; range 1-6).

In patients in whom the diagnosis of Multiple Sclerosis is not supported by abnormalities on Brain MRI, imaging of the Spinal Cord can be of considerable value.

Medical Texts
Anatomy | Immune System | Lymphocytes | Meds
MHC | Movement | Cranial Nerves | Physiology

MS Glossary ThJuland's MSers' Glen - Our CyberHome Page Top The Glen's Gallery: Come & Share Our Stories MS Files MS Abstracts Site Index

ANS | Bladder | Cognition | Fatigue | Fluid | Genetics
Interferons | IVIG | Nitric Oxide | Optic Neuritis | Pain
Physiology | Prions | Prognosis | ReMyelinate | Steroids
Stress | Treatments | TNF | Uric Acid | Viruses

Copyright 1997 - 2010:
Permission is granted to MS Societies and all MSers to utilize information from these pages provided that no financial reward is gained and attribution is given to the author/s.