Human HerpesVirus 6 And Multiple Sclerosis

  1. LeukoTropic HerpesViruses in Multiple Sclerosis
    Mult Scler 2000 Apr;6(2):66-68

  2. Detection of Human HerpesVirus 6 variant A in Multiple Sclerosis Peripheral Blood MonoNuclear Cells
    Eur Neurol 2000 Apr;43(3):170-173

  3. Absence of HHV-6 and HHV-7 in CerebroSpinal Fluid in Relapsing/Remitting Multiple Sclerosis
    Acta Neurol Scand 2000 Apr;101(4):224-8


LeukoTropic HerpesViruses
In Multiple Sclerosis

Hay KA, Tenser RB
Mult Scler 2000 Apr;6(2):66-68
Penn State Univ, College of Medicine, Dept of Medicine (Neurology), Hershey, Pennsylvania, USA
PMID# 10773849; UI# 20238093

Detection frequency of Human HerpesVirus 6 (HHV-6) and Epstein Barr Virus (EBV) DNA in Multiple Sclerosis (MS) patients and controls was investigated. DNA of Peripheral Blood MonoNuclear Leukocytes (PBL) was isolated and amplified by Polymerase Chain Reaction techniques.

EBV DNA was detected in all patients and controls. HHV-6 DNA was detected in 7% of MS patients and in 14% of controls.

Results are compared with other investigations of HHV-6 DNA in PBL, Serum, CSF and Brain of patients with MS.

Results of the present study and other investigations do not show an association between HHV-6 in PBL and MS.

Multiple Sclerosis (2000) 6, 66 - 68


Detection Of Human HerpesVirus 6 Variant A In Multiple Sclerosis Peripheral Blood MonoNuclear Cells

Kim J, Lee K, Park J, Kim M, Shin W
Eur Neurol 2000 Apr;43(3):170-173
Catholic Univ of Korea, Dept of Neurology, Seoul, South Korea
PMID# 10765058

Several authors report that Human HerpesVirus 6 (HHV-6) variants have different Epidemiologies, in vivo Tropism and Pathogenic potentials. However, it is not well known what Pathogenic roles its NeuroTropism might have in the variant type.

As some active Plaques of Multiple Sclerosis (MS) Brain tissue harbor HHV-6 DNA divergent from the prototype Virus, the possibility that the variant strain may play a role in the PathoGenesis of MS has been suggested.

Therefore, we tried to investigate the role of HHV-6 variants in the PathoGenesis of MS.

As HHV-6 is predominantly a T-Cell-Tropic Virus, we examined HHV-6 DNA sequences in Peripheral Blood MonoNuclear Cells (PBMC) from 34 MS patients, 6 with idiopathic Transverse Myelitis, 2 with Optic Neuritis and 20 healthy controls.

Nested polymerase chain reaction was used to detect the HHV-6 Genome. To discern HHV-6 variants A and B, amplification products were digested by restriction enzyme.

We found that 7 of 34 MS patients and 2 of 6 patients with idiopathic Transverse Myelitis had the HHV-6 Genome. On the contrary, there was no HHV-6 Genome in the control group. All Genomic sequences were of HHV-6 variant A (HHV-6A).

Our results suggest that the detection of HHV-6A in the PBMC of patients with MS may raise the possibility of a relationship between latent HHV-6A infection and the PathoGenesis of MS.

Copyright 2000 S. Karger AG, Basel


Absence Of HHV-6 And HHV-7 In CerebroSpinal Fluid In Relapsing/Remitting Multiple Sclerosis

Taus C, Pucci E, Cartechini E, Fie A, Giuliani G, Clementi M, Menzo S
Acta Neurol Scand 2000 Apr;101(4):224-8
Universita di Ancona, Istituto Malattie del Sistema Nervoso, Ancona, Italy
PMID# 10789987; UI# 20248898

To contribute to clarifying the controversy on the association between Human HerpesViruses 6 and 7 (HHV-6, HHV-7) and Multiple Sclerosis (MS) studying patients with Relapsing/Remitting MS (R/R-MS) with or without evidence of disease activity (clinically or radiologically evaluated).

Material And Methods
In 25 R/R-MS patients, 7 suspected MS patients and 9 patients with Other Neurological Diseases,

    The following parameters were analyzed:
  • AntiBody Titers (IgM and IgG) against HHV-6 by indirect ImmunoFluorescence both in Serum and CerebroSpinal Fluid (CSF) samples;

  • PCR-detection of HHV-6 DNA and HHV-7 DNA in CSF and HHV-6 DNA in Peripheral Blood MonoNuclear Cells (PBMCs).

MS patients in remission underwent a Gadolinium-enhanced Magnetic Resonance Imaging in proximity of sample collections.

No Viral DNA was found in any CSF sample, HHV-6 DNA frequency in PBMCs of MS patients and controls was not statistically different.

AntiBody Titers against HHV-6 were comparable to those of the general population. Some 30.4% of MS patients were SeroNegative to HHV6.

Our data suggest that there is no relationship between HHV-6 or HHV-7 and MS.

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